DAP kinase and DAP-3: novel positive mediators of apoptosis
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چکیده
منابع مشابه
DAP kinase and DAP-3: novel positive mediators of apoptosis.
Programmed cell death is a genetically controlled response for cells to commit suicide. The process, which displays distinctive morphological features, is highly conserved through evolution, and takes place in all nucleated animal cells. It is tightly controlled by environmental stimuli including extracellular diVusible factors, or membrane bound molecules that mediate cell-cell or cell-matrix ...
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Death-associated protein kinase (DAP-kinase) is a calcium/calmodulin-dependent serine/threonine kinase, and participates in various apoptosis systems. However, its apoptosis-promoting mechanism is poorly understood. Here, we demonstrate that DAP-kinase suppresses integrin-mediated cell adhesion and signal transduction, whereas dominant-negative interference of this kinase promotes adhesion. Thi...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1999
ISSN: 0003-4967
DOI: 10.1136/ard.58.2008.i14